Homologous gene conversion across different species

Homologous gene conversion across different species

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Here, we use three mouse genes as an example. The method is the same for more genes.

library(homologene)
genelist<-c("Acadm","Eno2","Acadvl")
homologene(genelist, inTax = 10090, outTax = 9606)
# Use homologene function for gene conversion
# genelist: the gene list to be converted
# inTax: the taxonomic ID of the species for the input gene list, 10090 for mouse
# outTax: the taxonomic ID of the species to convert to, 9606 for human

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result:

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The species IDs supported by Homologene

homologene::taxData

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For commonly used organisms like mice and humans, there are even dedicated functions available

mouse2human(genelist)

# and human to mouse
human2mouse(c("ACADM","ENO2","ACADVL"))
human2mouse(c("H1.2","TP53"))

# and dme to homo
genelist<-c("Sxl","msl-2")
homologene::taxData
homologene(genelist, inTax = 7227, outTax = 9606)

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ref : https://cloud.tencent.com/developer/article/2115727